Cannoodt, R., Saelens, W., Deconinck, L., & Saeys, Y. (2021).
Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells. Nature Communications, 12(1).
http://dx.doi.org/10.1038/s41467-021-24152-2
Abstract:
We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimulating development and testing of computational methods. We demonstrate its potential for spearheading computational methods on three applications: aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.
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